The AP-1 transcription factor Batf controls TH17 differentiation
نویسندگان
چکیده
منابع مشابه
BATF: bringing (in) another Th17-regulating factor.
T helper (Th) 17 cells are a recently identified subset of T cells that regulate tissue inflammation, and RORgammat and RORalpha have been shown to be Th17-specific transcription factors that mediate Th17 cell generation. A new study of Batf-deficient mice shows that this AP-1 family transcription factor also regulates Th17 cell differentiation by binding to Th17-associated gene promoters and b...
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T Helper-17 Differentiation and Function In the past decade, increasing attention has been focused on a subset of CD4 T cells, commonly known as T helper-17 (Th17) cells, which on differentiation specializes in the secretion of interleukin (IL)-17, and also others factors, such as IL-21, granulocyte–macrophage colony-stimulating factor, and IL-6. IL-17 cytokine family consists of 6 members; amo...
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ژورنال
عنوان ژورنال: Nature
سال: 2009
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature08114